Ramatroban, not only antagonist,but also can be used for asthma.

Ramatroban, not only antagonist,but also can be used for asthma.

Ramatroban (INN) is a thromboxane receptor antagonist.

http://www.ebiochem.com/product/ramatroban

It is also a CRTH2 antagonist. It is indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma.

The chemoattractant receptor-homologous molecule expressed on T_H2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D₂ receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.

It was developed by the German pharmaceutical company Bayer AG and is co-marketed in Japan by Bayer and Nippon Shinyaku Co. Ltd. under the tradename Baynas.