L-Lysine, one of nutritional supplement
Lysine. an essential amino acid, has a positively charged ε-amino group (a primary amine).
Lysine is basically alanine with a propylamine substituent on theβcarbon. The ε-amino group has a significantly higher pKa (about 10.5 in polypeptides) than does the α-amino group.The amino group is highly reactive and often participates in a reactions at the active centers of enzymes. Proteins only have one α amino group, but numerous ε amino groups. However, the higher pKa renders the lysyl side chains effectively less nucleophilic. Specific environmental effects in enzyme active centers can lower the pKa of the lysyl side chain such that it becomes reactive. Note that the side chain has three methylene groups, so that even though the terminal amino group will be charged under physiological conditions, the side chain does have significant hydrophobic character.
L-Lysine is an essential amino acid that is available as a nutritional supplement. It helps the body absorb calcium, and supports the creation of collagen. Evidence suggests that lysine may help treat cold sores and help prevent osteoporosis.
L-Lysine is linked to the production of carnitine coverts fatty acids into energy, which in turn reduces cholesterol in the bloodstream. Lysine has also been used to treat cold sores.Several studies were completed to text the effectiveness of taking L-Lysine supplements on a regular basis to control cold sore and genital herpes outbreaks. These studies had mixed results. While some groups concluded that this supplement prevented outbreaks, other studies showed that the Lysine supplements had no effect on the duration or timing of outbreaks.
In addition, it contributes to the producing of collagen (the protein which is used to make tendons, bone, connective tissue and cartilage). L-lysine also facilitates the absorbing and use of calcium, and it keeps the skin elastic and healthy as well.
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