Pregabalin is used with other medicines to help control partial seizures in the treatment of epilepsy. This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it.
Pregabalin is also used for postherpetic neuralgia (pain that occurs after shingles) and pain caused by nerve damage from diabetes or a spinal cord injury. It is used to treat a condition called fibromyalgia (muscle pain and stiffness).
Leslie J. Crofford studied the efficacy of pregabalin for treating symptoms of generalized anxiety disorder has been demonstrated in several clinical trials (42, 43). As such, it is possible that improvements in pain scores reported by patients could be a by-product of a positive anxiolytic effect. However, in the present trial, there were no significant changes in HADS anxiety scores at end point from those at baseline. This suggests that patient-reported changes in pain scores are not a product of improvements in symptoms of anxiety; rather, improvements in pain scores are independent of anxiety symptom status.
Usually the patient will on a low dose of pregabalin and increase it gradually, depending on the patient's evaluation. Its therapeutic effect appears after 1 week of use and is similar in effectiveness to lorazepam, alprazolam and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons
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