Precious Paclitaxel

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a U.S. National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel.

Function

Through the Ⅱ - Ⅲ clinical research, paclitaxel is mainly effective to ovarian cancer and breast cancer,lung cancer, colon cancer, melanoma, head and neck cancer, lymphoma, brain tumor are also have certain curative effect.

Pharmacology and toxicology

Paclitaxel is a new type anti-microtubules drug which inhibits potubulin depolymerization so as to keep tubulin stable, inhibit cell mitosis. Vitro studies shows that paclitaxel can significantly improves radiotherapy sensitization which will halt cells sensitive to radiotherapy stage G2 and stage M.

pharmacokinetic

Intravenous injection paclitaxel, drug plasma concentration shows two directions curve.Its protein binding rate is 89%-98%, paclitaxel is metabolized through liver. Actually, it is mainly metabolized through liver and then into intestinal tract,through faeces removed from the body.

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