Some new retrospective study from Georgetown University Medical Center, Omaha Creighton University and Jordan Science University, 6 to 12 weeks of bitter orange and its main composition p-synephrine supplements are not associated with increasing heart rate, elevated blood pressure or other side effects,but they have many health benefits including to promote metabolism and energy metabolism and control weight, etc.
Researchers analyzed more than 20 clinical research for 360 participants, 44% of them eat either bitter orange or p-synephrine supplement, 56% of them eating both bitter orange or p - synephrine combined with others. All the participants intake supplement every day for 12 weeks. Since more than half of the participants are fat or overweight, nearly two thirds of the participants also get 132 mg or 538 mg of caffeine every day.
Analyzes believed that bitter orange or p-synephrine single intake or with other components won't increase heart rate or raise blood pressure or side effects. Moreover, it won't change electrocardiogram, blood plasma chemical composition, blood count. There is no obvious difference in urine analysis.
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