Data published in Cancer Epidemiology, Biomarkers & Prevention found that frequent consumption of quercetin-rich food was associated with expression of a known tumor suppressor.
The findings provide suggestive insights into a possible mechanism to explain the inverse association between quercetin-rich food consumption and lung cancer risk observed in epidemiological studies.
The study adds to the steadily growing body of science supporting the potential benefits of quercetin, a flavonoid found in fruits and vegetables. Potential health benefits include lowering of inflammatory markers, cholesterol reduction, and improving blood pressure.
However, many of these potential benefits are the result of in vitro or animal studies and data from human studies is rare.
One such human study by researchers from the University of Utah did indicate that a daily 730 milligram supplement of quercetin led to significant reductions in blood pressure. This is the first time to report the blood pressure-lowering activity of this flavonol, was published in the Journal of Nutrition.
The new study indicates that quercetin may also benefit to cancer risk reduction. The NIH and Yale researchers analyzed the expression of microRNA in people with lung cancer. MicroRNAs are short, single-stranded RNAs involved in the expression of genes. Misregulated microRNAs are said to play a role in cancer development. MicroRNA data was analyzed for 264 lung cancer cases and quercetin intakes were assessed using a food-frequency questionnaire. Participants with quercetin is reported increased let-7, the material inhibits tomour.
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