Q10 might delay the process of Parkinson's Disease

Researchers in the university of California San Diego Branch used coenzyme Q10 for treatment of Parkinson's disease at early stage. The study indicated that coenzyme Q10 can delay the process of Parkinson's disease(PD).While the results must be confirmed in a larger study, they provide hope that this compound may ultimately provide a new way of treating Parkinson's Disease.

They looked at a total of 80 PD patients at 10 centers across the country to determine if coenzyme Q10 is safe and if it can slow the rate of functional decline.The investigators believe coenzyme Q10 works by improving the function of mitochondria, the "powerhouses" that produce energy in cells. Coenzyme Q10 is an important link in the chain of chemical reactions that produces this energy. It also is a potent antioxidant - a chemical that "mops up" potentially harmful chemicals generated during normal metabolism. Previous studies carried out by Dr. Shults, Richard Haas, M.D., of UCSD and Flint Beal, M.D., of Cornell University have shown that coenzyme Q10 levels in mitochondria from PD patients are reduced and that mitochondrial function in these patients is impaired. Animal studies have shown that coenzyme Q10 can protect the area of the brain that is damaged in PD. Dr. Shults and colleagues also conducted a pilot study with PD patients which showed that consumption of up to 800 mg/day of coenzyme Q10 was well-tolerated and significantly increased the level of coenzyme Q10 in the blood.The investigators found that most side effects of coenzyme Q10 were mild, and none of the patients required a reduction of their dose.

Multicenter clinical trial of coenzyme Q10 suggests that it can slow disease progression in patients with early-stage Parkinson's disease. Thus, the investigators are now planning a larger clinical trial that will examine the effects of 1,200 mg/day of coenzyme Q10 , and possibly a higher dose as well, in a larger number of patients.

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